Skip to content

What’s New in PET/CT

Prognostic values of baseline, interim and end-of therapy 18F-FDG PET/CT in patients with follicular lymphoma.

PET/CT Updates, Research & Education
September 2019

Purpose

In the present study, we aimed to investigate the role of baseline, interim and end-of treatment positron emission tomography/computed tomography (PET/CT) in assessing the prognosis of follicular lymphoma (FL).

Methods

A total of 84 FL patients were retrospectively analyzed in this study. Baseline (n=59), interim (n=24, after 2-4 cycles) and end-of treatment (n=43) PET/CT images were re-evaluated, and baseline maximum standardized uptake value (SUVmax), total metabolic tumor volume (tMTV) and total lesion glycolysis (TLG) were recorded. Interim (I-PET) and end-of treatment (E-PET) PET/CT responses were interpreted by Deauville five-point scale (D-5PS) and International Harmonization Project criteria (IHP). Survival curves were calculated by Kaplan-Meier curves, and differences between groups were compared by log-rank test.

Results

The 2-year progression-free survival (PFS) of the high- and low-TLG groups was 57.14% and 95.56%, respectively (p=0.0001). The 2-year overall survival (OS) of the high- and low-TLG groups was 62.50% and 100%, respectively (p<0.0001). Multivariate analysis showed that TLG was an independent prognostic factor for PFS (p=0.001, HR=6.577, 95% CI=2.167-19.960) and OS (p=0.030, HR=19.291, 95% CI =2.689-137.947). Besides, Eastern Cooperative Oncology Group (ECOG) was the independent prognostic factor for OS (HR=8.924, 95% CI=1.273-62.559, p=0.028). Interim PET results based on D-5PS or IHP criteria were not significantly correlated with PFS (all p>0.05). However, E-PET results using D-5PS and IHP criteria were statistically significant (p=0.0001 and p=0.006). The D-5PS showed stronger prognostic value compared with IHP criteria. The optimal cutoff value of ΔSUVmax% was 66.95% according to I-PET and 68.97% according to E-PET. However, only the ΔSUVmax% from the baseline to the end-of therapy yielded statistically significant results in the prediction of PFS (p=0.0002).

Conclusion

Our findings indicated that the baseline TLG and E-PET results were significantly associated with prognosis in patients with FL.

Source: Cancer Manag Res. 2019 Jul 23;11:6871-6885. doi: 10.2147/CMAR.S216445. eCollection 2019.
< https://www.ncbi.nlm.nih.gov/pubmed/31413633 > Retrieved 9 September 2019.

iStock_000023280434XLarge

September Lymphoma Awareness

  • Non-Hodgkin lymphoma (NHL) is one of the most common cancers in the United States, accounting for about 4% of all cancers
  • The American Cancer Society estimates that approximately 74,200 people (41,090 males and 33,110 females) will be diagnosed with NHL in the United States in 2019
  • The risk of developing NHL increases throughout life, and more than half of patients are 65 or older at the time of diagnosis

Connect with Us

Get additional information and stay up-to-date with the latest news by connecting with us on social media.