What’s New in PET/CT
Prognostic values of baseline, interim and end-of therapy 18F-FDG PET/CT in patients with follicular lymphoma.
PET/CT Updates, Research & Education
In the present study, we aimed to investigate the role of baseline, interim and end-of treatment positron emission tomography/computed tomography (PET/CT) in assessing the prognosis of follicular lymphoma (FL).
A total of 84 FL patients were retrospectively analyzed in this study. Baseline (n=59), interim (n=24, after 2-4 cycles) and end-of treatment (n=43) PET/CT images were re-evaluated, and baseline maximum standardized uptake value (SUVmax), total metabolic tumor volume (tMTV) and total lesion glycolysis (TLG) were recorded. Interim (I-PET) and end-of treatment (E-PET) PET/CT responses were interpreted by Deauville five-point scale (D-5PS) and International Harmonization Project criteria (IHP). Survival curves were calculated by Kaplan-Meier curves, and differences between groups were compared by log-rank test.
The 2-year progression-free survival (PFS) of the high- and low-TLG groups was 57.14% and 95.56%, respectively (p=0.0001). The 2-year overall survival (OS) of the high- and low-TLG groups was 62.50% and 100%, respectively (p<0.0001). Multivariate analysis showed that TLG was an independent prognostic factor for PFS (p=0.001, HR=6.577, 95% CI=2.167-19.960) and OS (p=0.030, HR=19.291, 95% CI =2.689-137.947). Besides, Eastern Cooperative Oncology Group (ECOG) was the independent prognostic factor for OS (HR=8.924, 95% CI=1.273-62.559, p=0.028). Interim PET results based on D-5PS or IHP criteria were not significantly correlated with PFS (all p>0.05). However, E-PET results using D-5PS and IHP criteria were statistically significant (p=0.0001 and p=0.006). The D-5PS showed stronger prognostic value compared with IHP criteria. The optimal cutoff value of ΔSUVmax% was 66.95% according to I-PET and 68.97% according to E-PET. However, only the ΔSUVmax% from the baseline to the end-of therapy yielded statistically significant results in the prediction of PFS (p=0.0002).
Our findings indicated that the baseline TLG and E-PET results were significantly associated with prognosis in patients with FL.
Source: Cancer Manag Res. 2019 Jul 23;11:6871-6885. doi: 10.2147/CMAR.S216445. eCollection 2019.
< https://www.ncbi.nlm.nih.gov/pubmed/31413633 > Retrieved 9 September 2019.
September Lymphoma Awareness
- Non-Hodgkin lymphoma (NHL) is one of the most common cancers in the United States, accounting for about 4% of all cancers
- The American Cancer Society estimates that approximately 74,200 people (41,090 males and 33,110 females) will be diagnosed with NHL in the United States in 2019
- The risk of developing NHL increases throughout life, and more than half of patients are 65 or older at the time of diagnosis
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